Posts Tagged: UC Davis
Call it serendipity. Call it a major collaborative effort. Call it a keen eye for science.
Whatever you call it, research that sprang from studies on insect pest control in the Bruce Hammock lab at the
We all know of people suffering from heart failure, which occurs when the heart can’t pump enough blood throughout the body. The condition affects 5 million people in the
The research in the laboratories of cardiologist and cell biologist Nipavan Chiamvimonvat, Department of Cardiovascular Medicine, UC Davis School of Medicine, and entomologist Bruce Hammock, Department of Entomology, showed that the new class of drugs reduces heart swelling in rat models with heart failure.
“This holds promise to treat heart failure and other cardiovascular as well as kidney problems,” said nephrology professor Robert Weiss, Department of Internal Medicine.
Similar compounds are now in clinical trials.
"The study of rat models showed that heart failure is driven by high angiotensin associated with high blood pressure, artery disease and some kidney disease,” Hammock said. “When that occurs, a key enzyme called soluble epoxide hydrolase is increased."
The 11-member research team showed they could inhibit the enzyme with a drug made by Paul Jones, a former postgraduate researcher at UC Davis. The swelling and ultimate failure of the heart is blocked and reversed, Hammock said.
“Interestingly, the increase in heart size associated with extreme exercise does not increase levels of the epoxide hydrolase, and exercise induced heart enlargement fortunately is not blocked by the drug.”
This research follows earlier studies reported from the Chiamvimonvat laboratory on cardiac hypertrophy. The two UC Davis laboratories collaborated with the laboratories of John Shyy at UC Riverside and Yi Zhu, Cardiovascular Sciences,
The paper, “Soluble Epoxide Hydrolase Plays an Essential Role in Angiotensin II-Induced Cardiac Hypertrophy,” is online.
This is definitely a significant discovery that could result in saving scores of lives. And to think it all started with the Hammock lab discovering an enzyme inhibitor that regulates insect larvae development.
She enclosed $20 from her allowance savings.
Hannah Fisher Gray, 11, of
Hannah collected $110 at her birthday party and then contributed $110 from her own money so that both UC Davis and
The girls are the newest bee crusaders, said Lynn Kimsey, chair of the UC Davis Department of Entomology and director of the Bohart Museum of Entomology.
“These are very generous gifts from the heart,” Kimsey said. “It’s very touching that these girls would take a special interest in helping us save the honey bees.”
Hannah, a fifth grader from
In the letter, Hannah expressed her concern “about our environment and its creatures, especially the honey bees.”
“I saw the Häagen-Dazs commercial and I instantly wanted to learn more,” she wrote. “I researched about bees and learned ways I could help, such as donating money, using honey instead of sugar, planting honeybee-friendly plants and supporting beekeepers.”
“For my birthday party, I asked my guests to make gifts of money to support honeybee research instead of giving presents for me. The total of these gifts was $110. I am making a matching gift of $110 of my own money, and splitting the gift between the
One of Hannah’s birthday gifts was a T-shirt proclaiming “Bee a Hero.” And, in keeping with her passion for bees, she dressed in a honey bee costume last Halloween.
Hannah learned of the troubling bee crisis from the national Häagen-Dazs campaign, launched Feb. 19 to create awareness for the plight of the honey bee. Nearly 40 percent of Häagen-Dazs brand ice cream flavors are linked to fruits and nuts pollinated by bees.
Katie Brown learned of the plight of the honey bees through the Häagen-Dazs Web site, www.helpthehoneybees.com.
Her mother, Molly Pont-Brown, said that Katie "gets a portion of her allowance each week for charity and had been wanting to help the bees and saving up for a long time, so we were looking online for ways to help the bees and stumbled upon their (Häagen-Dazs) program.”
In her donation letter to UC Davis, Katie drew the Häagen-Dazs symbol, “HD Loves HB,” and two smiling bees. She signed her name with three hearts.
Eager to share information with her classmates on the plight of the honey bees, Katie took photos of foods that bees pollinate and served Honey Bee Vanilla ice cream, the new flavor that Häagen-Dazs created last year as part of its bee crisis-awareness campaign.
Katie is "about to give another $40 additionally from her Star Student Week," her mother said. The six-year-old chose to donate $2 per child to the honey bee research program instead of buying the customary trinkets for them. Katie also sent each classmate a “bee-mail” from the Häagen-Dazs Web site to let them know about it.
For Christmas, Katie received a Häagen-Dazs bee shirt and bee books from her family. Her grandmother in
“What a great thing (the drive to save the bees) for Häagen-Dazs to do,” Molly Pont-Brown wrote in a letter to UC Davis. “And, of course, we appreciate all your department is doing to help the very important honeybees with your research, as well!”
When told of the
As part of its national campaign, Häagen-Dazs last February committed a total of $250,000 for bee research to UC Davis and
The Häagen-Dazs brand is also funding a design competition to create a half-acre honey bee haven garden at the Harry H. Laidlaw Jr. Honey Bee Research Facility at UC Davis. The deadline to submit entries is Jan. 30.
UC Davis Extension Apiculturist Eric Mussen, a member of the UC Davis Department of Entomology faculty for 32 years, said the bee population "still has not recovered from previous losses." Some of the nation's beekeepers have reported losing one-third to 100 percent of their bees due to colony collapse disorder (CCD), in which bee mysteriously abandon their hives. He attributes CCD to multiple factors, including diseases, parasites, pesticides, malnutrition, stress and climate change.
"Bees pollinate about 100 agricultural crops, or about one-third of the food that we eat daily," Mussen said.
Those interesting in donating to the honey bee research program at UC Davis or learning more about the design competition for the honey bee haven can access the Department of Entomology home page.
Letter to bee scientists
Hannah Fisher Gray
If you've been around honey bee hives much, you know what a smoker is.
It's a tool that beekeepers use to inspect, manipulate or handle a hive. They smoke a hive to check the health of the colony, to add a little food, and to take a little honey.
In a way, it's a form of "blowin' smoke" or a deception.
Moses Quinby of St. Johnsville, N.Y. invented the modern-day bee smoker in 1875. He created a firepot with bellows and a nozzle. Ancient Egyptians used pottery filled with smoldering cow dung to smoke the hives.
Why smoke? Smoke calms the bees. It masks the smell of the pheromone that the guard bees release to alert other bees of "trouble in River City." The bees smell the smoke and gorge on honey in preparation for The Big Move.
Pure and simple.
The result: mass confusion. And that leaves plenty of time for the beekeepers to go about their business.
As a child, I loved the old bee smoker that my father used to tend the hives. We marveled at the contraption that bellowed like an accordion and snorted puffs of smoke. Sometimes my father would pump the bellows and teasingly blow smoke toward us.
Today, over at the Harry H. Laidlaw Jr. Honey Bee Research Facility at UC Davis, I watched bee breeder-geneticist Susan Cobey and assistant Elizabeth Frost smoke the hives and feed pollen to the bees.
They placed the smoker on a table and it kept blowing smoke. It curled into clouds and swirled into stripes and all I could think of was one word.
Pure and simple.
Chemical ecologists at the University of California, Davis, are changing their navel-orangeworm research direction after an elementary school student’s science project found that the major agricultural pest prefers pistachios over almonds and walnuts.
Gabriel Leal, 11, a sixth grader at Willet Elementary School, Davis, prefers pistachios over all other nuts so he figured that the navel orangeworm (NOW) would, too.
“Pistachios taste better,” reasoned Gabriel, whose family says he can eat an entire bag of pistachios at one sitting. Pistachios have long been his favorite nut, so why wouldn’t the navel orangeworm prefer pistachios over almonds and walnuts, too?
So the sixth grader hypothesized that the insect would lay more eggs in pistachios than in almonds and walnuts, contrary to widely published research that indicates an almond preference.
“Everybody knows that navel orangeworms prefer almonds,” said his father, Walter Leal, a chemical ecologist and professor of entomology at UC Davis. Research published recently in the California Agriculture journal also indicates the preference.
“But in science,” Leal said, “we should believe what we see, not what others tell us. I know that Gabriel prefers pistachios, but I assumed the navel orangeworm’s taste receptors were different.”
Wrong. Gabriel’s research showed that the insects preferred pistachios, just like him.
The findings led to a report at the Almond Board of California’s 32nd Almond Industry Conference, held Dec. 1-2 in Modesto, and launched a new direction of navel orangeworm chemical ecology research at UC Davis
Gabriel performed his research in his father’s UC Davis lab, under the volunteer supervision and mentoring of chemical ecologist Zain Syed.
“It was a ‘choice’ experiment where Gabriel placed mated and gravid (egg-filled) females in a cage,” Syed said. “He used four commercially available navel orangeworm traps (Ovitraps). One trap was filled with 50 grams of shelled pistachios, another with 50 grams of almonds, and the third with 50 grams of walnuts. The empty trap served as the control to check if the trap itself had any effects on attracting egg-laying moths. The eggs laid in the ovitraps were counted for two consecutive nights.”
Said Leal: "Gabriel got enough replicates to demonstrate that female orange navelworms do prefer pistachios over walnuts and almonds. We are very excited with our little scientist’s discovery. I reported ‘our’ findings at the state almond industry conference in Modesto. And these findings changed our research direction, because we are now interested in determining what chemistry in pistachios attracts female navel orangeworms.”
“Oviposition (egg-laying) attractants derived from almond oil are used to monitor female populations in the field,” Leal explained, “but during hull split, the chemical from the natural source (crop) competes with the synthetic material in traps. If we use pistachio-derived attractants in the almond field there will be no competition throughout the flight season.”
So how significant a pest is the navel orangeworm?
According to research entomologist Brian Higbee of Paramount Farming, Bakersfield, "it is the primary and most destructive pest on almonds and pistachios." California has some 152,000 acres planted in pistachios, while the state's almond acreage totals more than 700,000.
"The economic impact of NOW damage varies from year to year, but it can easily reach $10-15 million for our company and much higher statewide," Higbee said.
The take-home message? "Well, in science we should never underestimate anyone's idea,” Leal said. “That's why the academic environment is so enriching: students come with new ideas, but I never imagined we would benefit so much from a science project for elementary school."
For more, see news story on the UC Davis Department of Entomology Web site.
Young scientist Gabriel Leal
I always thought the red-hot poker was primarily red.
This one in the Storer Gardens at the University of California, Davis, was mostly yellow.
It was Saturday, Dec. 20, 2008, five days before Christmas, and a lone honey bee, packed with pollen, was heading for the red-hot poker, variety "Christmas Cheer" (Kniphofia).
Seemed quite appropriate.
Red-Hot Poker in Storer Gardens