Posts Tagged: Thomas Scott
So are researchers from the Thomas Scott lab at UC Davis.
Scott, a medical entomologist who directs the state-funded UC Mosquito Research Laboratory, and his field director Amy Morrison, based in Iquitos, Peru, know their foe well.
Their goal: to save lives through research, surveillance and implementation of disease prevention strategies.
Morrison talked about the research efforts today on National Public Radio (NPR).
Morrison told Charles: ""What's fascinating to me about aegypti is it's probably the mosquito that's most closely associated with human beings, and the most adapted to human beings."
The tiger-striped mosquito, is a daybiting mosquito that prefers human blood. Some 2.5 to 3 billion people, primarily in tropical and sub-tropical countries around the world, are at risk for dengue, which Scott describes as "the world's worst insect-transmitted disease." See feature on him on the UC Davis Department of Entomology website, with links to significant research work.
Aedes aegypti is out for blood. And so are the UC Davis-based researchers tracking it.
Aedes aegypti transmits dengue. (Photo courtesy of James Gathany, Centers for Disease Control and Prevention).
It's not just high temperatures that play a significant role in the transmission of dengue, a deadly mosquito-borne disease that strikes millions of people in tropical and subtropical countries.
The size and pattern of fluctuations in daily temperature have a large effect on pathogens transmitted by mosquitoes, according to groundbreaking research published today in the Proceedings of the National Academy of Sciences.
The research, led by French, Thailand and U.S. scientists and conceived by medical entomologist Thomas Scott (right) of the UC Davis Department of Entomology, targets the transmission of spread of dengue.
Lead author Louis Lambrechts (left) of the Institut Pasteur, France, who did postdoctoral research in the Scott lab, points out that the influence of average temperatures on dengue virus transmission has long been known–the higher the temperature, the more efficient the virus transmission—but this is the first study linking temperature fluctuations to the transmission of the disease.
Dengue, transmitted by the daybiting Aedes aegypti mosquito, globally infects 50 to 100 million people yearly. At risk are some 2.5 to 3 billion people, primarily in tropical and sub-tropical countries. The most severe form of the disease, dengue haemorrhagic fever (DHF), strikes half a million a year and kills an estimated 5 percent, according to the Centers for Disease Control and Prevention.
Scott said the study helps to explain a long-standing enigma: “What are the underlying causes of seasonal fluctuations in dengue incidence?” Experiments showed that mosquitoes die faster and are less susceptible to virus infection under large temperature swings, which is typical of the low dengue season, than under moderate temperature variation, which is typical of the high dengue season.
Scott, a noted dengue expert whose goal is to save lives through research, surveillance and implementation of disease prevention strategies, has a longstanding interest in the factors that drive seasonal and annual fluctuations in diseases caused by mosquito-transmitted pathogens. “Traditional explanations for the seasonal increase in dengue are not consistent with my experience in Thailand, Peru, and Puerto Rico,” Scott said.
The dengue mosquito, Aedes aegypti. (Photo courtesy of James Gathany, Centers for Disease Control and Prevention).
Three University of California entomology professors were among the 10 newly elected Fellows of the Entomological Society of America (ESA) honored at the organization's 58th annual meeting, held Dec. 12-15 in San Diego.
Their selection speaks highly of the caliber of UC professors. No more than 10 Fellows are selected for the honor every year from the 6000-member organization, and this year the UC system has three.
They are Bruce Hammock and Thomas Scott of UC Davis and Thomas A. Miller of UC Riverside.
Hammock, a distinguished professor of entomology, studies "inhibitors of epoxide hydrolases as drugs to treat diabetes, inflammation, ischemia and cardiovascular disease," the ESA statement of his work reads. "Compounds from the UC Davis laboratory are in human trials."
That in itself--from bench to bedside--is unique in the annals of entomology.
Hammock, a member of the UC Davis Medical Center's Cancer Center and the National Academy of Sciences, is not only a distinguished professor but a highly sought-after mentor who draws students to his lab from all over the world.
Scott, who directs the UC Mosquito Research Laboratory at Davis, is one of the key "go-to" researchers studying dengue. When he's not in his UC Davis lab, you can usually find him doing research in Peru, Thailand or Mexico. Scott is especially known for his research on mosquito ecology, evolution of mosquito virus interactions, epidemiology of mosquito-borne disease, and evaluation of novel products and strategies for mosquito control and disease prevention.
Scott is a fellow of the American Association for the Advancement of Science and is a past president of the Society for Vector Ecology. He serves as a subject editor for the American Journal of Tropical Medicine and Hygiene. (More on Hammock and Scott on the UC Davis Department of Entomology website.)
ESA officials pointed out that Miller's research "has included structure and function of the insect circulatory system; mode of action of insecticides; insect neuromuscular physiology; physiology, toxicology and behavior of pink bollworm in cotton fields; transgenic insects; and applied symbiosis for crop protection and biopesticides for crop protection. "
Miller's university teaching includes insect physiology, insect toxicology and first year biology. Current projects include control of bush cricket pests of oil palm trees in Papua New Guinea, oversight of field trials of transgenic grapevines with resistance to Pierce's disease, biotechnology for control of desert locust, and regulatory control of insect transgenic technologies.
In 2003 Miller was awarded the Gregor J. Mendel Medal for Research in Biological Sciences by the Czech Academy of Sciences. That's just one of his many honors.
Indeed, the list of honors and accomplishments for these three UC entomologists could easily fill a book!
Thomas Scott (right), professor of entomology at the University of California, Davis, and a newly elected fellow of the Entomological Society of America, knows his foe well.
His foe? The day-biting, tiger-striped mosquito, Aedes aegypti. It transmits a virus that causes dengue, sometimes called "break-bone fever."
It's the world’s worst insect-transmitted virus.
And it's on the rise.
"Spread by mosquitoes, it can make you feel as if your bones are broken and leave you exhausted for months," writes Zimmer, who teaches Yale University students how to write about science and the environment. "In more serious cases, people suffer uncontrollable bleeding and sometimes die. Dengue is expanding its range, and is even making incursions into the United States. Scott and I talk about what scientists know and don't know yet about dengue, and what the best strategy will be to drive the virus down."
When Scott leaves his mosquito research laboratory at UC Davis, he’s likely heading for his field stations in Peru, Thailand or Mexico to try to stop that killer mosquito from transmitting dengue.
Scott’s goal: to save lives through research, surveillance and implementation of disease prevention strategies.
“I study the patterns of human infection with dengue virus, doing detailed studies of mosquito populations and disease in humans in order to predict which prevention strategies work the best,” said Scott, who assesses risks, develops computer models and implements disease prevention strategies.
The culprit: Aedes aegypti, or the yellow-fever mosquito, that transmits dengue virus to people.
The disease: Dengue, caused by any one of four serotypes or closely related viruses known as DEN-1, DEN-2, DEN-3, or DEN-4. Nicknamed “break-bone fever,” classic dengue is characterized by high fever, headaches, muscle and joint pain, nausea, vomiting and a rash.
At risk: Some 2.5 to 3 billion people, primarily in tropical and sub-tropical countries around the world.
The prevalence: Some 50 to 100 million annual cases of debilitating dengue fever. The most severe form of the disease, dengue haemorrhagic fever (DHF), strikes half a million a year, according to the Centers for Disease Control and Prevention. An estimated 5 percent with DHF die.
There’s no vaccine. There’s no cure. The only way to prevent this disease is to kill the mosquito vector.
Scott directs the state-funded UC Mosquito Research Laboratory, based in Briggs Hall on the UC Davis campus. His team includes UC Davis associate professor and medical entomologist Anthony “Anton” Cornel, based at the Kearney Agricultural Center, Parlier; researcher Amy Morrison who lives in Iquitos, Peru and has directed their research there since 1999; program manager Leslie Sandburg; postdoctoral and graduate students; and a long list of collaborators at his field sites in Mexico, Peru and Thailand.
Listen to the podcast and learn how Thomas Scott (who at 6-foot, 6 inches tall, towers over his tiny foe) is battling this killer.
(Editor's note: Professor Scott will be teaching a winter course on medical entomology at UC Davis, discussing such diseases as malaria, dengue, West Nile virus, lyme disease, yellow fever, and river blindness.)
The Entomological Society of America this morning announced the 2010 Fellows. Each year the governing board can elect up to 10 members as Fellows of the 6000-member society.
The highly prestigious honor acknowledges outstanding contributions in one or more of the following: research, teaching, extension, or administration.
This year...drum roll...three UC professors were among the 10 selected: Bruce Hammock and Thomas Scott of UC Davis and Thomas Miller of UC Riverside.
They will be inducted as Fellows at the ESA’s annual meeting, to be held Dec. 12-15 in San Diego.
Hammock (top photo), a distinguished professor of entomology and a member of the National Academy of Sciences, joined the UC Davis Department of Entomology faculty in 1980 and holds a joint appointment with the UC Davis Cancer Research Center.
Hammock and his laboratory are exploiting inhibitors of epoxide hydrolases as drugs to treat diabetes, inflammation, ischemia, and cardiovascular disease. Compounds from the UC Davis laboratory are in human trials.
Diabetes, arthritis and heart patients are closely following his research.
Thomas Scott (middle photo) joined the UC Davis Department of Entomology Department in 1996 and directs the UC Davis Mosquito Research Laboratory. A fellow of the American Association for the Advancement of Science, Scott is a past president of the Society for Vector Ecology and co-founder of the Center for Vector-Borne Research.
Scott’s research focuses on mosquito ecology, evolution of mosquito-virus interactions, epidemiology of mosquito-borne disease, and evaluation of novel products and strategies for mosquito control and disease prevention.
He's a noted authority on the mosquito-borne disease, dengue.
Thomas Miller (lower photo) received his doctorate in entomology from UC Riverside in 1967. His research has included the structure and function of the insect circulatory system; mode of action of insecticides; insect neuromuscular physiology; physiology, toxicology and behavior of pink bollworm in cotton fields; transgenic insects; and applied symbiosis for crop protection and biopesticides for crop protection.
Current projects include control of bush cricket pests of oil palm trees in Papua New Guinea, oversight of field trials of transgenic grapevines with resistance to Pierce's disease, biotechnology for control of desert locust, and regulatory control of insect transgenic technologies.
These three entomologists have published widely--Hammock alone has 763 peer-reviewed publications.
Indeed, their accomplishments could fill several books.
Thomas Scott in Kenya