Posts Tagged: malaria
Anopheles gambiae, the mosquito that transmits malaria, has a new foe.
And his first name is Win.
Win Surachetpong, a UC Davis doctoral candidate in immunology with a designed emphasis in vector-borne disease, has just received the American Committee of Medical Entomology student travel award to present his malaria research at the 58th annual American Society of Tropical Medicine and Hygiene (ASTMH) conference Nov. 18-22 in Washington, D.C.
That's quite an honor, indeed.
Surachetpong studies with noted malaria researcher Shirley Luckhart, an associate professor of medical microbiology and immunology at UC Davis.
“Win’s work has demonstrated for the first time that signaling pathways that are well known for immune responsiveness in humans to Plasmodium infection are also important for the mosquito response to parasite infection,” said Luckhart, a faculty member of the Graduate Program in Entomology, and the Graduate Groups of Biochemistry and Molecular Biology; Microbiology; and Immunology.
“Win will be presenting exciting unpublished work that moves forward from his recent publication in PLoS Pathogens,” she said.
Also by invitation, Surachetpong will discuss his research at the adjoining meeting of the American Committee of Molecular, Cellular and Immunoparasitology, a unit of ASTMH that fosters the transfer of fundamental discoveries in basic research to applications that improve human health.
Malaria, caused by the parasite Plasmodium and transmitted by infected anophelene mosquitoes, strikes some 350 to 500 million people a year, killing more than a million. (Above: The photo of Anopheles gambiae is by UC Davis medical entomologist Anthony "Anton" Cornel, based at the UC Kearney Agricultural Center, Parlier.)Luckhart (at left) said that Win is “working simultaneously on three different, inter-related, redox-regulated signal transduction pathways that will move our current state of knowledge forward significantly when he is through.”
“There are no commercially available tools (such as antibodies, reagents for knockout) that have been designed to study these signaling pathways in invertebrate cells, much less mosquito cells,” she said.
Surachetpong is adapting available tools for mammalian cell studies to his work and developing the remaining tools and reagents on his own. “His data comprised nearly all of the preliminary data for a new NIH grant that will allow us to move forward into new and exciting areas in anti-malarial innate immunity,” Luckhart said.
Earlier this year, Surachetpong won the 2009 William C. Reeves New Investigator Award, a statewide award which acknowledges the best scientific paper submitted and presented at the annual Mosquito and Vector Control Association of California conference.
A native of Thailand, Surachetpong received his doctor of veterinary science degree at Chulalongkorn University, Bangkok in 2000, ranking first in his class, and his master of science degree in pathobiology in 2005 from the University of Arizona, where he received the “Above and Beyond Award” from the Department of Veterinary Science and Microbiology.
After completing his doctorate at UC Davis, Surachetpong will join the faculty at Kasetsart University, Bangkok, to continue his research on tropical and emerging infectious diseases.
As a medical entomologist and immunologist, his goal is to utilize his expertise in vector-borne diseases and innate immunity to improve malaria transmission control in Thailand and other endemic countries.
What's medical entomolology?
Anyone who's an entomologist or who works in entomology is asked that question periodically. Medical, they know. Entomology? Often not. But medical entomology?
Well, it's the study of relationships among arthorpods, microbial pathogens and human health, according to medical entomologist Thomas Scott, professor of entomology at UC Davis.
Scott teaches courses on medical entomology. His next one: the 2009 winter quarter, Jan. 5 through March 16.
Worldwide, Scott says, arthropod-borne diseases have devastating effects on human health; they are a leading cause of human morbidity and mortality.
In his course, he explains the basic biology of medically important arthropods and the pathogens they transmit. The diseases include malaria, dengue fever, yellow fever, West Nile virus, Lyme disease and River Blindness.
Scott, a noted mosquito-borne disease expert and newly elected fellow of the prestigious American Association for the Advancement of Science (for "distinguished contributions to the biology and ecology of mosquitoes and his leadership in developing strategic concepts for preventing dengue fever and other mosquito-borne diseases”) does research from his mosquito research laboratory at UC Davis and at field stations in Peru, Thailand and Mexico.
In January, Scott hosted the 42nd annual U.S.-Japan Parasitic Disease Conference on the UC Davis campus. Some 100 scientists from throughout the world participated in the three-day conference "to develop a cross-cutting perspective on what the priorities should be for the future research on arthropod vectors of disease," he explained.
With new and emerging diseases, increasing national and international travel, settlement in endemic areas, and the proliferation of commerce, we can expect disease from vector-borne pathogens to increase, Scott says.
It's obvious what we need less of (diseases) and what we need more of (medical entomologists).
Thomas Scott in Kenya
Mosquito that tranmits dengue