Targeting the Malaria Mosquito
Bradley White, assistant professor at UC Riverside, will speak on “Ecological Genomics of Malaria Mosquitoes” at the UC Davis Department of Entomology seminar from 12:05 to 1 p.m. in Room 1022 of the Life Sciences Building, corner of Hutchison and Kleiber Hall drives.
Professor Gregory Lanzaro of the UC Davis School of Veterinary Medicine will introduce White. Plans call for video-recording the seminar for later posting on UCTV.
"Anopheles gambiae is the most important malaria vector in the world,” White says in is abstract. “Remarkable adaptive flexibility has enabled this mosquito to track humans across the diverse ecoclimates of sub-Saharan Africa where it thrives in both highly mesic and xeric conditions. These rapid, recent ecological adaptations have driven incipient speciation into two ecotypes, which differentially exploit permanent and temporary larval habitats. Within each nascent species, abundant chromosomal inversion polymorphisms facilitate adaptation to local conditions along latitudinal environmental gradients."
“To elucidate the genetic basis of ecological adaptation in Anopheles gambiae, we performed a series of genome-wide divergence scans, which revealed candidate regions subject to recent natural selection. Dissection of one of these genomic regions established a link between naturally occurring allelic variation and an adaptive phenotype. In the context of evolutionary genomics, these studies shed light on the maintenance of inversion polymorphisms and also provide insight into the genomic architecture of reproductive isolation. From a public health standpoint, this work demonstrates how divergent ecological selection can impact the vectorial capacity of Anopheles gambiae -- with consequences for malaria epidemiology and control.”
White began working on mosquitoes as an undergraduate at Oberlin College in Ohio. “At the time, West Nile virus (WNV) was sweeping through the midwest and during the summers I participated in a project to identify the Culex vectors of WNV and to determine environmental factors affecting their abundance,” he said. “After leaving Oberlin, I spent the next seven years in Nora Besansky's lab at Notre Dame where I focused on the population genomics of the African malaria mosquito Anopheles gambiae."
White, who joined the UC Riverside Department of Entomology faculty in 2011, focuses his research on quantitative and functional genomics of Anopheline malaria vectors.
More information? Check out his website at http://www.mosquitogenomics.org.
The malaria mosquito, Anopheles gambiae. (Photo by Anthony Cornel)